Unwinding of a DNA replication fork by a hexameric viral helicase

Autor: Abid Javed, Balazs Major, Jonathan A. Stead, Cyril M. Sanders, Elena V. Orlova
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-25843-6
Popis: Replicative hexameric helicases are fundamental components of replisomes. Here the authors resolve a cryo-EM structure of the E1 helicase from papillomavirus bound to a DNA replication fork, providing insights into the mechanism of DNA unwinding by these hexameric enzymes.
Databáze: Directory of Open Access Journals