Dual Antiplatelet Therapy in Patients Aged 75 Years and Older with Coronary Artery Disease: A Meta-Analysis and Systematic Review

Autor: Garly Saint Croix, Spencer C. Lacy, Amre Gazzhal, Michel Ibrahim, Medeona Gjergjindreaj, Jorge Perez, Malik Shehadeh, Karthik Vedantam, Christian Torres, Nirat Beohar, Esteban Escolar
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Interventional Cardiology, Vol 2022 (2022)
Druh dokumentu: article
ISSN: 1540-8183
DOI: 10.1155/2022/3111840
Popis: Objectives. This systematic review and meta-analysis evaluates the safety and efficacy of dual antiplatelet therapy (DAPT) in elderly patients with acute coronary syndrome (ACS). Background. The safety and efficacy of DAPT in elderly patients with ACS is not well characterized. Methods. We performed a systematic literature review to identify clinical studies that reported safety and efficacy outcomes after DAPT for ACS in elderly patients. The primary outcomes of primary efficacy endpoint rates and bleeding event rates were reported as random effects risk ratio (RR) with 95% confidence interval. No prior ethical approval was required since all data are public. Results. Our search yielded 660 potential studies. We included 8 studies reporting on 29,217 patients. There was a higher risk of bleeding event rates in elderly patients treated with prasugrel or ticagrelor when compared to clopidogrel with a risk ratio of 1.17 (95% CI 1.08 to 1.27, p
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