Risk Factors for Pandemic (H1N1) 2009 Virus Seroconversion among Hospital Staff, Singapore
| Autor: | Mark I.C. Chen, Vernon J.M. Lee, Ian Barr, Cui Lin, Rachelle Goh, Caroline Lee, Baldev Singh, Jessie Tan, Wei-Yen Lim, Alex R. Cook, Brenda Ang, Angela Chow, Boon Huan Tan, Jimmy Loh, Robert Shaw, Kee Seng Chia, Raymond T.P. Lin, Yee Sin Leo |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Emerging Infectious Diseases, Vol 16, Iss 10, Pp 1554-1561 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1080-6040 1080-6059 |
| DOI: | 10.3201/eid1610.100516 |
| Popis: | We describe incidence and risk factors for pandemic (H1N1) 2009 virus infection in healthcare personnel during the June–September 2009 epidemic in Singapore. Personnel contributed 3 serologic samples during June–October 2009, with seroconversion defined as a >4-fold increase in hemagglutination inhibition titers to pandemic (H1N1) 2009. Of 531 participants, 35 showed evidence of seroconversion. Seroconversion rates were highest in nurses (28/290) and lowest in allied health staff (2/116). Significant risk factors on multivariate analysis were being a nurse (adjusted odds ratio [aOR] 4.5, 95% confidence interval [CI] 1.0–19.6) and working in pandemic (H1N1) 2009 isolation wards (aOR 4.5, 95% CI 1.3–15.6). Contact with pandemic (H1N1) 2009–infected colleagues (aOR 2.5, 95% CI 0.9–6.6) and larger household size (aOR 1.2, 95% CI 1.0–1.4) were of borderline significance. Our study suggests that seroconversion was associated with occupational and nonoccupational risk factors. |
| Databáze: | Directory of Open Access Journals |
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