Investigation of miR-222 as a potential biomarker in diagnosis of patients with methamphetamine abuse disorder

Autor: Shima Fathi, Hossein Soltanzadeh, Asghar Tanomand, Zahra Asadi, Saman Rezai Moradali
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Egyptian Journal of Medical Human Genetics, Vol 23, Iss 1, Pp 1-6 (2022)
Druh dokumentu: article
ISSN: 2090-2441
DOI: 10.1186/s43042-022-00281-1
Popis: Abstract Background Methamphetamine abuse disorder is an important social and health problem worldwide. Diagnosis and confirmation of patients with methamphetamine abuse using serum are important in many fields. MicroRNAs (miRNAs) are small non-coding oligonucleotides and recently suggested as a biomarker for earlier diagnosis of several human disorders. Therefore, in this study, we investigated miR-222 and miR-212 expressions in blood of patients with methamphetamine abuse disorder comparison with healthy control subjects. Results The results revealed that the expression of blood miR-222 is significantly increased (12.9-fold change) in patients with methamphetamine abuse disorders compared to healthy controls (p 0.05). Conclusions In general, we suggested that the miR-222 may play a potentially important role in pathogenesis of methamphetamine abuse disorder and can be considered as an applied tool for identifying individuals with methamphetamine abuse disorder.
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje