| Autor: |
Peishang Li, Jian Wu, Yuechen Li, Chentao Luo, Hongzhang Zhang, Haofeng Tang, Ying Wu, Xiangsheng Kong |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Alexandria Engineering Journal, Vol 107, Iss , Pp 166-173 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1110-0168 |
| DOI: |
10.1016/j.aej.2024.07.047 |
| Popis: |
This study reports the development and evaluation of yttrium-90 (90Y) radiolabeled silica-coated iron oxide (SiO2-Fe3O4) resin microspheres for potential theranostic application in cancer radiation therapy. Iron oxide nanoparticles of average diameter 29.7 nm were synthesized via optimized co-precipitation and displayed superparamagnetic behavior ideal for MRI. Aminosilane surface functionalization enabled covalent conjugation of 1 mmol/g DTPA/DOTA chelators for labeling 2 mCi 90Y per 150 μg nanoparticles with 92 % efficiency when incubated for 45 mins at pH 5.5 and 50°C. In vitro stability assays in buffers and human serum showed excellent 90Y retention (>95 %) up to 48 hours. In vivo biodistribution in Wistar rats revealed extended nanoparticle circulation half-life of 5.2 hours and peak exposure of 22.4 %ID/g compared to rapid clearance of unconjugated 90Y chloride within 1 hour. Complete renal recovery by 72 hours and minimal bone accumulation ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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