The Evolving Landscape of Male Varicocele Pathophysiology in the Era of Multi-Omics: A Narrative Review of the Current Literature

Autor: Carlos Munoz-Lopez, Anne Wong, Kieran Lewis, Raevti Bole, Sarah C. Vij, Scott D. Lundy
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Biology, Vol 13, Iss 2, p 80 (2024)
Druh dokumentu: article
ISSN: 13020080
2079-7737
DOI: 10.3390/biology13020080
Popis: Male-factor infertility is implicated in over half of the millions of cases of infertility worldwide, and varicoceles are the most common correctable cause of male-factor infertility. The pathophysiologic mechanism for varicoceles is complex and next-generation technologies offer promising insights into the molecular underpinnings of this condition. In this narrative review, we highlight historical and contemporary paradigms associated with varicoceles, with an emphasis on the biological underpinnings of this disease. Specifically, we review the literature describing the underlying causes of varicoceles, discuss the molecular and cellular mechanisms causing pathological changes in some (but not all) men, and highlight key articles regarding the next-generation analyses (e.g., transcriptome, epigenome, proteome, and microbiome) being applied to better understand the condition and its treatment. These data demonstrate an ongoing evolution of the knowledge of varicoceles and the potential for improved personalized care in the future for men with this condition.
Databáze: Directory of Open Access Journals