Foveal and Retinal Nerve Fiber Layer Thickness in Children With a History of Retinopathy of Prematurity Treated With Bevacizumab: A Cross-sectional Study

Autor: Amir Eftekhari Milani, Bahareh Javani, Mohamadhosein Ahoor, Mehdi Abdi Shahshahani, Fereshteh Farhadi
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Crescent Journal of Medical and Biological Sciences, Vol 10, Iss 4, Pp 169-175 (2023)
Druh dokumentu: article
ISSN: 2148-9696
DOI: 10.34172/cjmb.2023.27
Popis: Objectives: This study aimed to investigate the effects of bevacizumab (an anti-VEGF antibody) on the structure of retina such as the thickness of the nerve fiber layer and macula with optical coherence tomography (OCT) in retinopathy of prematurity (ROP) patients. Materials and Methods: This cross-sectional study was conducted in 2021-2022 in Tabriz, Iran to investigate preterm children aged 4-6 years. To this end, a total of 300 eyes of 150 children were assigned to three groups and then were examined by performing Fundus examination of retina, eye refraction test, and OCT imaging. The first group included 100 eyes with a history of ROP and treated with bevacizumab, the second group consisted of 100 eyes with a history of ROP but improved spontaneously, and the third group comprised 100 eyes of preterm children without a history of ROP. Results: Foveal thickness was 235.46 ± 11 µm in the group receiving bevacizumab, 267.70 ± 12 µm in the group with spontaneous improvement of ROP, and 269.48 ± 10 µm in the group with no ROP. Therefore, the mean thickness of the fovea in the group receiving bevacizumab was significantly lower than that in the other two groups. In the group receiving bevacizumab, moreover, the thickness of the nerve layer of the retina was less than that in the other two groups (P
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