| Autor: |
Debora Santonocito, Giuseppina Raciti, Agata Campisi, Giovanni Sposito, Annamaria Panico, Edy Angela Siciliano, Maria Grazia Sarpietro, Elisabetta Damiani, Carmelo Puglia |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Nanomaterials, Vol 11, Iss 2, p 391 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2079-4991 |
| DOI: |
10.3390/nano11020391 |
| Popis: |
Alzheimer’s disease (AD) is a neurodegenerative disorder associated with marked oxidative stress at the level of the brain. Recent studies indicate that increasing the antioxidant capacity could represent a very promising therapeutic strategy for AD treatment. Astaxanthin (AST), a powerful natural antioxidant, could be a good candidate for AD treatment, although its use in clinical practice is compromised by its high instability. In order to overcome this limit, our attention focused on the development of innovative AST-loaded stealth lipid nanoparticles (AST-SSLNs) able to improve AST bioavailability in the brain. AST-SSLNs prepared by solvent-diffusion technique showed technological parameters suitable for parenteral administration ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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