| Autor: |
Ayat Abu-elnasr Awwad, Rehab A. Hasan, Mohamed Ghazy Attia Hablas, Osama Mohammad Mohammad Abdelhay, Yahia Mohmmed Ahmed Dawood, Bothina Ahmed Mohamed, Khadiga Abdallah Abd Rabou, Taghreed Mahmoud Mohamed Salem, Marwa Elhady, Gehad Nabil Abd El-Aal, Ahmed Helal Elsayed Ahmed, Ahmed Ibrahim Mostafa Hasan, Asmaa Abd Elsalam Elmadbouly, Mohamed Basiouny Yahia, Walaa Mohamed Omar Ashry, Said S. M. M. El Sayed, Ashraf M. M. Algendy, Ahmad M. F. Alkot, Mohamed F. Farag, Ashraf Abdel Aty El Shenawy Emara, Fayez Mohammed Abd Elfattah Elbayoumy, Hany Fawzy Ali, Mohamed Morshdy Aldesoky, Raafat Abd-Rabow Abd-Eltwab, Samia M. Manawy, Eman Mohamed Faruk |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-023-33970-x |
| Popis: |
Abstract Inflammatory processes are increasingly attributed to macrophage polarization. Proinflammatory macrophages promote T helper (Th) 1 response, tissue repair, and Th2 responses. Detection of macrophages in tissue sections is facilitated by CD68. Our study is focused on the expression of CD68 and the estimation of proinflammatory cytokines in children’s patients with chronic tonsillitis secondary to vitamin D supplementation. This hospital-based Randomized prospective case–control study was conducted on 80 children with chronic tonsillitis associated with vitamin D deficiency where (40 received vitamin D 50,000 IU weekly for 3–6 months and 40 received 5 ml distilled water as placebo). The serum 25-hydroxyvitamin D [25(OH)D] was measured using an Enzyme-linked immunosorbent assay on all included children. Different histological and immunohistochemical studies for the detection of CD68 were done. There was a significantly lower serum level of 25(OH)D in the placebo group versus the vitamin D group (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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