Clinical Remission of Immunoglobulin A Nephropathy after Bariatric Surgery in a Young Morbidly Obese Patient

Autor: Vaibhav Tiwari, Anurag Gupta, Veronica Arora, Pallav Gupta, Suviraj John, Smita Divyaveer, Vinant Bhargava, Manish Malik, Ashwani Gupta, Anil K. Bhalla, Devinder S. Rana
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Saudi Journal of Kidney Diseases and Transplantation, Vol 32, Iss 6, Pp 1813-1819 (2021)
Druh dokumentu: article
ISSN: 1319-2442
DOI: 10.4103/1319-2442.352447
Popis: A 23-year-old girl with morbid obesity, diabetes mellitus, hypertension, obstructive sleep apnea, and immunoglobulin A nephropathy (IgAN) attended a bariatric clinic after multiple failed attempts at weight loss. In the past, she was diagnosed with IgAN with nephrotic syndrome and raised blood pressure at the age of 11 years. Apart from optimization of blood pressure with angiotensin receptor blocker, she required steroid to maintain her remission in initial four years which was later switched to mycophenolate mofetil (MMF). She was diagnosed with diabetes at the age of 13 years; her blood sugars remained poorly controlled despite therapy with oral hypoglycemic agents and insulin. She underwent sleeve gastrectomy with no post-operative complications. During the follow-up, she showed a steady reduction in her weight, along with maintaining normal blood sugars and pressure without medications. At 18 months of follow-up, IgAN remained in remission after stopping MMF at four months after the surgery. Obesity is considered an important cofactor in the progression of IgAN. This case highlights the importance of weight reduction to halt the progression of the disease.
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