Diagnostics and treatment challenges of Ph-like acute lymphoblastic leukemia: a description of 3 clinical cases
| Autor: | K I ZARUBINA, E N PAROVICHNIKOVA, G A BASKHAEVA, A E KRASILNIKOVA, O A GAVRILINA, B V BIDERMAN, A B SUDARIKOV, S N BONDARENKO, Y O DAVYDOVA, I V GALTSEVA, A N SOKOLOV, V V TROITSKAYA, V G SAVCHENKO |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Терапевтический архив, Vol 90, Iss 7, Pp 110-117 (2018) |
| Druh dokumentu: | article |
| ISSN: | 0040-3660 2309-5342 |
| DOI: | 10.26442/terarkh2018907110-117 |
| Popis: | B-cell acute lymphoblastic leukemia (B-ALL) is a diverse group of malignant blood disorders both with regard to the biological properties of the tumor and to therapeutic approaches. Immunophenotyping, molecular genetic techniques, whole-genome sequencing characterize B-ALL as a very diverse group for sensitivity to chemotherapy and prognosis. We present three clinical cases of patients with B-ALL and expected good response to standard therapy, in whom standard protocol treatment failured: refractoriness, persistence of minimal residual disease (MRD), and progression (MRD increase). The remission in these patients was achieved after chemotherapy change to immunological targeted therapy. Nowadays a unified therapeutic approach to all primary patients of the B-ALL is considered generally outdated. Great efforts are carrying out to develop molecular genetic classifications. The molecular dissection of subtypes of B-ALL goes on, and new protocols for selective treatment with targeting are clearly outlined for each subtype of B-ALL. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|