| Autor: |
Marijke I. Zonneveld, Martijn J.C. vanHerwijnen, Marcela M. Fernandez‐Gutierrez, Alberta Giovanazzi, Anne Marit deGroot, Marije Kleinjan, Toni M.M. vanCapel, Alice J.A.M. Sijts, Leonie S. Taams, Johan Garssen, Esther C. deJong, Michiel Kleerebezem, Esther N.M. Nolte‐’t Hoen, Frank A. Redegeld, Marca H.M. Wauben |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of Extracellular Vesicles, Vol 10, Iss 5, Pp n/a-n/a (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2001-3078 |
| DOI: |
10.1002/jev2.12071 |
| Popis: |
Abstract Maternal milk is nature's first functional food. It plays a crucial role in the development of the infant's gastrointestinal (GI) tract and the immune system. Extracellular vesicles (EVs) are a heterogeneous population of lipid bilayer enclosed vesicles released by cells for intercellular communication and are a component of milk. Recently, we discovered that human milk EVs contain a unique proteome compared to other milk components. Here, we show that physiological concentrations of milk EVs support epithelial barrier function by increasing cell migration via the p38 MAPK pathway. Additionally, milk EVs inhibit agonist‐induced activation of endosomal Toll like receptors TLR3 and TLR9. Furthermore, milk EVs directly inhibit activation of CD4+ T cells by temporarily suppressing T cell activation without inducing tolerance. We show that milk EV proteins target key hotspots of signalling networks that can modulate cellular processes in various cell types of the GI tract. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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