Renal denervation inhibits the renin–angiotensin–aldosterone system in spontaneously hypertensive rats

Autor:	Fei Qin, Jianling Li, Yong-Fa Dai, Xiao-ge Zhong, Ya-jin Pan
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	renal denervation renin–angiotensin–aldosterone system aldosterone angiotensin ii type-1 receptor angiotensin ii Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	Clinical and Experimental Hypertension, Vol 44, Iss 1, Pp 83-92 (2022)
Druh dokumentu:	article
ISSN:	1064-1963 1525-6006 10641963
DOI:	10.1080/10641963.2021.1996587
Popis:	This study was conducted to explore the effect of renal denervation (RDN) on the renin–angiotensin–aldosterone system (RAAS) in spontaneously hypertensive rats (SHRs). Our experimental rats were randomly divided into the RDN group conducted by painting 10% phenol on the bilateral renal nerves (RDNX), the shamoperation group simply painting with saline (Sham), and the normotension control group (WKY) following all the animal blood and tissues of kidney, hypothalamus, and adrenal gland collected and examined 2 weeks after RDN operation. We found that the aldosterone (ALD) levels in serum and tissues all decreased in the RDNX group compared with the Sham group (p
Databáze:	Directory of Open Access Journals
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