| Autor: |
Lesong Li, Tao Liu, Xiaoli Zhang, Xiaohan Hou, Hao Dong, Xiaoyang Li, Weiwu Ren, Yang Wang |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Green Synthesis and Catalysis, Vol 3, Iss 1, Pp 69-78 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2666-5549 |
| DOI: |
10.1016/j.gresc.2021.11.005 |
| Popis: |
A highly efficient and environmentally benign 1,3-dipolar cycloaddition of C,N - cyclic azomethine imines with 5-alkenyl thiazolones and 2-arylidenindane-1,3-diones is developed for the construction of congested quaternary spiro-carbon centers. All these transformations can be smoothly performed in ethanol at room temperature, providing a catalyst-free and atom-economical access to diversely substituted novel isoquinoline-fused spirocycles in almost quantitative yields with high diastereoselectivities. The promising anti-tumor activity of these structurally novel spirocyclic compounds is reported as well. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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