Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo
| Autor: | Robert A Benson, Megan KL MacLeod, Benjamin G Hale, Agapitos Patakas, Paul Garside, James M Brewer |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | eLife, Vol 4 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2050-084X 14903776 |
| DOI: | 10.7554/eLife.06994 |
| Popis: | The production of high affinity, class switched antibodies produced by B cells hinges on the effective differentiation of T follicular helper (Tfh) cells. Here we define conditions specifically enhancing Tfh differentiation and providing protection in a model of influenza infection. Tfh responses were associated with prolonged antigen presentation by dendritic cells (DCs), which maintained T cell/DC interactions into stage 3 (>72 hr) of activation. Blocking stage 3 interactions ablated Tfh generation, demonstrating a causal link between T cell-DC behaviour and functional outcomes. The current data therefore explain how duration of antigen presentation affects the dynamics of T cell-DC interactions and consequently determine Tfh cell differentiation in the developing immune response. |
| Databáze: | Directory of Open Access Journals |
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