| Autor: |
Simon Geisler, Simon D. Lytton, Nguyen Linh Toan, Trinh Huu Nghia, Nguyen Minh Nam, Hoang Vu Hung, Nguyen Thai Son, Do Tuan Anh, Hoang Tien Tuyen, Tran Viet Tien, Do Quyet, Hoang Van Tong, Nghiem Xuan Hoan, Le Huu Song, Srinivas Reddy Pallerla, Johanna M. Gostner, Dietmar Fuchs, Thirumalaisamy P. Velavan |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
International Journal of Infectious Diseases, Vol 91, Iss , Pp 162-168 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1201-9712 |
| DOI: |
10.1016/j.ijid.2019.12.005 |
| Popis: |
Objectives: During dengue fever, a pronounced gamma-interferon immune response produces neopterin and promotes tryptophan degradation by the enzyme indoleamine-2,3-dioxygenase 1 (IDO-1). Activated IDO-1 is indicated by an increased kynurenine to tryptophan ratio (Kyn/Trp) in patients. Methods: Plasma levels of neopterin, kynurenine, and tryptophan were measured in 72 hospitalized dengue virus (DENV) patients and 100 healthy individuals. Plasma levels of neopterin, kynurenine, and tryptophan were also measured prospectively in a second cohort of 13 DENV patients; on the day of hospitalization, on day 2–3 at discharge, and 7–10 days after discharge. DENV RNA positivity was determined by qualitative and quantitative methodologies. Results: DENV RNA-positive patients presented significantly higher levels of neopterin (mean 36.5 nmol/l) and Kyn/Trp ratios (mean 102 μmol/mmol) compared to DENV RNA-negative individuals. A significant correlation between neopterin levels and Kyn/Trp ratios was observed in both DENV RNA-positive (Spearman’s rho = 0.37, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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