| Autor: |
Jin Wan, Xiao-Feng Zhao, Anne Vojtek, Daniel Goldman |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Cell Reports, Vol 9, Iss 1, Pp 285-297 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
2211-1247 |
| DOI: |
10.1016/j.celrep.2014.08.048 |
| Popis: |
Summary: Müller glia (MG) in the zebrafish retina respond to retinal injury by generating multipotent progenitors for retinal repair. Here, we show that Insulin, Igf-1, and fibroblast growth factor (FGF) signaling components are necessary for retina regeneration. Interestingly, these factors synergize with each other and with heparin-binding EGF-like growth factor (HB-EGF) and cytokines to stimulate MG to generate multipotent progenitors in the uninjured retina. These factors act by stimulating a core set of signaling cascades (Mapk/Erk, phosphatidylinositol 3-kinase [PI3K], β-catenin, and pStat3) that are also shared with retinal injury and exhibit a remarkable amount of crosstalk. Our studies suggest that MG both produce and respond to factors that stimulate MG reprogramming and proliferation following retinal injury. The identification of a core set of regeneration-associated signaling pathways required for MG reprogramming not only furthers our understanding of retina regeneration in fish but also suggests targets for enhancing regeneration in mammals. : Müller glia are responsible for mediating retina regeneration in zebrafish. Wan et al. report on signaling systems activated by injury and necessary for retina regeneration. They identify a variety of growth factors and cytokines that stimulate Müller glia proliferation and retina regeneration by activating Mapk, Pi3k, β-catenin, and pStat3 signaling pathways. Their studies reveal a remarkable synergy and crosstalk among the growth factors and cytokines and provide evidence that this crosstalk is necessary for Müller glia proliferation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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