Transcranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia

Autor:	Roman Gersner, Carmen Paredes, Mustafa Q. Hameed, Sameer C. Dhamne, Alvaro Pascual‐Leone, Alexander Rotenberg
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Zdroj:	Annals of Clinical and Translational Neurology, Vol 7, Iss 3, Pp 384-389 (2020)
Druh dokumentu:	article
ISSN:	2328-9503
DOI:	10.1002/acn3.50981
Popis:	Abstract Automated anesthesia systems that continuously monitor cortical excitability (CE) changes to govern drug infusion rates, are desirable. Paired‐pulse transcranial magnetic stimulation (ppTMS), with electromyography (EMG), provides noninvasive CE measures. We tested whether, and with what temporal resolution, ppTMS‐EMG detects dose‐dependent CE in rats anesthetized with continuous intravenous propofol. Motor‐evoked potentials (MEPs) were recorded every 20 seconds as either propofol bolus or change in infusion rate was applied. ppTMS‐derived measures varied in direct proportion to propofol dose with subminute temporal resolution. We conclude that ppTMS‐EMG enables real‐time markers of target engagement by anesthetics that may be incorporated into an automated device.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/a323175ca9f64ce9a1baf0e1da5b78b3 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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