| Autor: |
Maria Joana Catarata, Margarida Lourenço, Maria Fátima Martins, João Frade, Alice Pêgo, Carlos Robalo Cordeiro, Rui Medeiros, Ricardo Ribeiro |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Pulmonology, Vol 27, Iss 2, Pp 116-123 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2531-0437 |
| DOI: |
10.1016/j.pulmoe.2020.11.007 |
| Popis: |
Introduction: AGXT gene codes for the enzyme alanine glyoxylate aminotransferase, which is involved in hepatic peroxisomal metabolism of platinum-based chemotherapeutic agents. The association of genetic variant AGXT rs34116584 on the clinical outcome and response to chemotherapy of patients with non-small cell lung cancer (NSCLC) remains to be established. Our aim was to evaluate the association of functional AGXT gene polymorphism in NSCLC progression, considering as primary and secondary endpoint, progression free survival (PFS) and overall survival (OS), respectively. Methods: Genotyping of theAGXT rs34116584 genetic polymorphism was performed by mass spectrometry on 168 DNA samples from patients with NSCLC (stages IIIA-IVB). Univariate survival analysis included the study of Kaplan-Meier curves with the Log-Rank test, while Cox regression was used as a multivariate analysis. Results: Multivariate analysis showed shorter PFS for T carriers [HR = 2.0, 95% CI, 1.4−3.0, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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