The relationship between immediate postmastectomy reconstruction modalities and survival benefits in patients with triple negative breast cancer

Autor: Luyao Dai, Hanxiao Cui, Yuanhang Bao, Liqun Hu, Zhangjian Zhou, Meng Wang, Shuai Lin, Hao Wu, Huafeng Kang, Xiaobin Ma
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Cancer Medicine, Vol 12, Iss 3, Pp 2782-2794 (2023)
Druh dokumentu: article
ISSN: 2045-7634
DOI: 10.1002/cam4.5166
Popis: Abstract Introduction Immediate postmastectomy reconstruction for breast cancer has been widely used due to its unique esthetic and psychological effects. However, no other population‐based study has investigated the effects of different reconstruction types on the survival in patients with triple negative breast cancer (TNBC). Methods We selected patients who met the eligibility criteria from the Surveillance, Epidemiology, and End Results cancer registry (N = 9760). We then assessed the effect of different reconstructive surgical approaches (implant, autologous, implant and autologous combined reconstruction) on the overall survival (OS) and breast cancer‐specific survival (BCSS) by using the Kaplan–Meier survival curve and Cox proportional hazard regression analyses. The nomograms were used to predict OS and BCSS. And the competitive risk model was used to assess breast cancer‐specific death (BCSD) and non‐breast cancer‐specific death (NBCSD). Results Statistical analysis suggested that the three reconstruction methods had better OS and BCSS with lower hazard than mastectomy alone (log‐rank test, p 60 years of age. The survival prediction model quantified the survival benefits of TNBC patients undergoing different surgeries. Moreover, the C‐indexes showed the good predictive ability of the nomograms. Conclusions Our results suggest that for TNBC patients, there is a survival benefit of immediate postmastectomy reconstruction compared with mastectomy alone. Among them, implant reconstruction has the most obvious advantage.
Databáze: Directory of Open Access Journals
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