| Autor: |
Thomas Wanek, Lara Schöllbauer, Thomas Filip, Severin Mairinger, Michael Sauberer, Matthias Blaickner, Claudia Kuntner |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Frontiers in Physics, Vol 8 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2296-424X |
| DOI: |
10.3389/fphy.2020.00123 |
| Popis: |
Background: Whole-body PET images can be obtained by using the “step-and-shoot” (SaS) method (using multiple bed positions) or continuous bed motion (CBM). As transmission scans are not always feasible, an alternative method where attenuation data can be generated via emission-based attenuation correction (AC) maps is of interest. The aim of this preclinical study was to investigate the influence of the acquisition method and AC on the quantitation accuracy of [18F]FDG-PET.Methods: [18F]FDG-PET phantom images were acquired using either SaS or CBM. Transmission scans were recorded for the SaS method using a 57Co-point source. Emission-based attenuation sinograms were obtained from the images after segmentation and inverse Fourier rebinning. PET images were reconstructed without AC, transmission based (TX-AC) and emission-based (EM-AC) attenuation correction. Moreover, [18F]FDG-PET scans of rats bearing mammary carcinomas acquired using either SaS or CBM were analyzed retrospectively and quantification in tissues was compared.Results: Phantom recovery coefficients (RC) varied greatly, ranging from 0.49 ± 0.01 to 1.15 ± 0.07, dependent on acquisition method, reconstruction algorithm and AC method. In CBM acquired images, EM-AC improved quantification accuracy when compared to no-AC images in the phantom studies (RC 0.79 ± 0.02 vs. 0.49 ± 0.01, respectively) and in tumors of rats (DMBA model: 1.16±0.42 SUV vs. 0.86±0.28 SUV, respectively).Conclusion: The method of AC has a strong influence on the quantification of [18F]FDG. Our data indicates that EM-AC improves quantification in images obtained by CBM and SaS. However, the obtained values were still underestimated when compared to TX-AC corrected images. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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