DYNAMICS OF BRAIN ENZYMES ACTIVITY IN RAT EXPOSED TO HYPOXIA
| Autor: | A. M. Rashidova, S. N. Babazadeh, V. V. Mammedkhanova, E. Sh. Abiyeva |
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| Jazyk: | English<br />Ukrainian |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Biotechnologia Acta, Vol 12, Iss 4, Pp 42-49 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2410-7751 2410-776X |
| DOI: | 10.15407/biotech12.04.042 |
| Popis: | The aim of the work was to study the dynamics of lactate dehydrogenase (LDH; EC 1.1.1.27), aconitase (AH; EC 4.2.1.3), NAD-dependent malate dehydrogenase (MDH; EC 1.1.1.37), succinate dehydrogenase (SDH; EC 1.3.99.1) activity in homogenates and sub-fractions of brain structures of rat prenatally endured hypoxia at the organogenesis stage (on 11–15 days of development) and their role in the formation of compensatory — adaptive mechanisms in brain in postnatal ontogenesis. It was revealed that increasing of lactate dehydrogenase and malate dehydrogenase activity (P < 0.001; P < 0.01, correspondently) in the brain structures of the rats prevented metabolic disturbances in the regulation mechanisms of biosynthetic and bioenergetics processes in the brain. It was shown that prenatal hypoxia upregulates aconitase activity in postnatal development and this process, probably, had a reversible character (P < 0.01), the highest indices of succinate dehydrogenase activity were noticed in the hypothalamus and cerebellum of 30-day-old rat as compared to the other structures (P |
| Databáze: | Directory of Open Access Journals |
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