Autor: |
Lei Yan, Ji Dong Zhang, Bo Wang, Yi Jing Lv, Hong Jiang, Gui Lin Liu, Yun Qiao, Ming Ren, Xue Feng Guo |
Jazyk: |
angličtina |
Rok vydání: |
2013 |
Předmět: |
|
Zdroj: |
PLoS ONE, Vol 8, Iss 9, p e72548 (2013) |
Druh dokumentu: |
article |
ISSN: |
1932-6203 |
DOI: |
10.1371/journal.pone.0072548 |
Popis: |
BACKGROUND: Quercetin is the most abundant flavonoid in fruit and vegetables and is believed to attenuate cardiovascular disease. We hypothesized that quercetin inhibits cardiac hypertrophy by blocking AP-1 (c-fos, c-jun) and activating PPAR-γ signaling pathways. METHODOLOGY/PRINCIPAL FINDINGS: The aim of this study was to identify the mechanism underlying quercetin-mediated attenuation of cardiac hypertrophy. Quercetin therapy reduced blood pressure and markedly reduced the ratio of left ventricular to body weight (LVW/BW) (P |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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