Systems biology approach to study the high altitude adaptation in tibetans

Autor:	Bi De, Xiao Huajun, Zhou Cuihong, Zhou Jun, Deng Xiaoyan, Liu Xiaopeng
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	systems biology Tibetan high-altitude adaptation single nucleotide polymorphism microRNA Biotechnology TP248.13-248.65
Zdroj:	Brazilian Archives of Biology and Technology, Vol 56, Iss 1, Pp 53-60 (2013)
Druh dokumentu:	article
ISSN:	1516-8913 1678-4324
Popis:	The aim of this work was to study an integrative systems biology research strategy to construct a network including the protein-protein interactions (PPIs) and microRNAs (miRNAs) and identify the functional biological processes and pathways for high-altitude adaptation in Tibetans. The pathway enrichment analysis revealed that the genes in the network were mainly involved in signling the pathways and the function of microRNAs was concentrated in the signling pathways, which suggested that miRNAs might contribute to the Tibetans high-altitude adaptation through the participation in signaling pathway. These results contribute to better understanding on the high-altitude adaptation of the Tibetans.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/e31ea83f4e4b4750bdedf601b7b90320 Zobrazit plný text záznamu View record in DOAJ