| Autor: |
Cassidy N.G. Erdelyan, Ahmed Kandeil, Anthony V. Signore, Megan E.B. Jones, Peter Vogel, Konstantin Andreev, Cathrine Arnason Bøe, Britt Gjerset, Tamiru N. Alkie, Carmencita Yason, Tamiko Hisanaga, Daniel Sullivan, Oliver Lung, Laura Bourque, Ifeoluwa Ayilara, Lemarie Pama, Trushar Jeevan, John Franks, Jeremy C. Jones, Jon P. Seiler, Lance Miller, Samira Mubareka, Richard J. Webby, Yohannes Berhane |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Cell Reports, Vol 43, Iss 7, Pp 114479- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2211-1247 |
| DOI: |
10.1016/j.celrep.2024.114479 |
| Popis: |
Summary: Highly pathogenic avian influenza (HPAI) viruses have spread at an unprecedented scale, leading to mass mortalities in birds and mammals. In 2023, a transatlantic incursion of HPAI A(H5N5) viruses into North America was detected, followed shortly thereafter by a mammalian detection. As these A(H5N5) viruses were similar to contemporary viruses described in Eurasia, the transatlantic spread of A(H5N5) viruses was most likely facilitated by pelagic seabirds. Some of the Canadian A(H5N5) viruses from birds and mammals possessed the PB2-E627K substitution known to facilitate adaptation to mammals. Ferrets inoculated with A(H5N5) viruses showed rapid, severe disease onset, with some evidence of direct contact transmission. However, these viruses have maintained receptor binding traits of avian influenza viruses and were susceptible to oseltamivir and zanamivir. Understanding the factors influencing the virulence and transmission of A(H5N5) in migratory birds and mammals is critical to minimize impacts on wildlife and public health. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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