| Autor: |
Yves Renaudineau, Dominique Chauveau, Stanislas Faguer, Antoine Huart, David Ribes, Gregory Pugnet, Laurent Sailler, Thibaut Jamme, Emmanuel Treiner, Françoise Fortenfant, Chloé Bost, Caroline Carlé, Julie Belliere |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Translational Autoimmunity, Vol 9, Iss , Pp 100244- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2589-9090 |
| DOI: |
10.1016/j.jtauto.2024.100244 |
| Popis: |
Lupus nephritis (LN) diagnosis and follow-up requires noninvasive biomarkers. Therefore, the added value of coupling the urinary soluble (s)CD163/creatinuria ratio with serological markers was evaluated in a real-world clinical practice. To this end, a monocentric and retrospective study was conducted in 139 SLE patients with biopsy-proven nephritis having an active LN (LN-A, n = 63 with a positive SLEDAI-renal score) or inactive (n = 76), as well as 98 non-renal SLE patients. The urinary sCD163/creatinuria ratio outperformed serological markers for predicting LN-A (AUC>0.972; p 0.750 versus non-LN patients, and AUC>0.640 versus LN-IR patients) best predicted LN-A, and higher levels were retrieved in class III/IV proliferative LN-A. In multivariate logistic regression analysis, the urinary sCD163/creatinuria ratio remained the only statistically significant biomarker to predict LN-A (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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