Accrual of organ damage in Behçet’s syndrome: trajectory, associated factors, and impact on patients’ quality of life over a 2-year prospective follow-up study

Autor: Alberto Floris, Matteo Piga, Riccardo Laconi, Gerard Espinosa, Giuseppe Lopalco, Luisa Serpa Pinto, Nikolaos Kougkas, Jurgen Sota, Andrea Lo Monaco, Marcello Govoni, Luca Cantarini, George Bertsias, João Correia, Florenzo Iannone, Ricard Cervera, Carlos Vasconcelos, Alessandro Mathieu, Alberto Cauli
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-8 (2022)
Druh dokumentu: article
ISSN: 1478-6362
DOI: 10.1186/s13075-022-02947-y
Popis: Abstract Background This study aimed to investigate the trajectory of damage accrual, associated factors, and impact on health-related quality of life (HR-QoL) in a multicenter cohort of patients with Behçet’s syndrome (BS) over 2 years of follow-up. Methods Patients recruited in the BS Overall Damage Index (BODI) validation study were prospectively monitored for 2 years and assessed for damage accrual, defined as an increase ≥1 in the BODI score, and HR-QoL was evaluated by the SF-36 questionnaire. Logistic and multiple linear regression models were built to determine factors associated with damage accrual and impairment in the different SF-36 domains. Results During follow-up, 36 out of 189 (19.0%) patients had an increase ≥1 in the BODI score with a mean (SD) difference of 1.7 (0.8) (p
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