| Autor: |
Huynh Truc, Hwang Sun, Bandell Michael, Peier Andrea M, Petrus Matt, Olney Nicholas, Jegla Tim, Patapoutian Ardem |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
Molecular Pain, Vol 3, Iss 1, p 40 (2007) |
| Druh dokumentu: |
article |
| ISSN: |
1744-8069 |
| DOI: |
10.1186/1744-8069-3-40 |
| Popis: |
Abstract Mechanical hyperalgesia is a clinically-relevant form of pain sensitization that develops through largely unknown mechanisms. TRPA1, a Transient Receptor Potential ion channel, is a sensor of pungent chemicals that may play a role in acute noxious mechanosensation and cold thermosensation. We have developed a specific small molecule TRPA1 inhibitor (AP18) that can reduce cinnameldehyde-induced nociception in vivo. Interestingly, AP18 is capable of reversing CFA-induced mechanical hyperalgesia in mice. Although TRPA1-deficient mice develop normal CFA-induced hyperalgeisa, AP18 is ineffective in the knockout mice, consistent with an on-target mechanism. Therefore, TRPA1 plays a role in sensitization of nociception, and that compensation in TRPA1-deficient mice masks this requirement. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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