First-in-human results of an in-body tissue architecture-induced tissue-engineered vascular graft 'Biotube' for application in distal bypass for chronic limb-threatening ischemia

Autor: Ryuji Higashita, MD, PhD, Manami Miyazaki, MD, Masaya Oi, MD, PhD, Noboru Ishikawa, MD, PhD
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Vascular Surgery Cases and Innovative Techniques, Vol 8, Iss 3, Pp 488-493 (2022)
Druh dokumentu: article
ISSN: 2468-4287
DOI: 10.1016/j.jvscit.2022.07.007
Popis: Small-diameter vascular substitutes remain necessary, especially in the absence of an available autologous vein. Using a completely autologous approach termed “in-body tissue architecture,” a small-diameter, long, tissue-engineered vascular graft, a “Biotube,” was developed. A below-the-knee distal bypass using the Biotube as a composite with expanded polytetrafluoroethylene grafts was performed to treat a patient with chronic limb-threatening ischemia without a venous graft available. The wound on the foot had completely healed 3 months after the bypass surgery, and limb salvage and walking without claudication were achieved. At the 1-year postoperative follow-up examination, duplex ultrasound scans demonstrated graft patency without thrombus or stenosis.
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