Acetic Acid-Induced Ulcerative Colitis in Sprague Dawley Rats Is Suppressed by Hydroethanolic Extract of Cordia vignei Leaves through Reduced Serum Levels of TNF-α and IL-6

Autor: George Owusu, David D. Obiri, George K. Ainooson, Newman Osafo, Aaron O. Antwi, Babatunde M. Duduyemi, Charles Ansah
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: International Journal of Chronic Diseases, Vol 2020 (2020)
Druh dokumentu: article
ISSN: 2356-6981
2314-5749
DOI: 10.1155/2020/8785497
Popis: Background. Ulcerative colitis (UC) is a recurrent inflammatory bowel disease (IBD) that causes long-lasting inflammation on the innermost lining of the colon and rectum. Leaf decoctions of Cordia vignei have been used in traditional medicine either alone or in combination with other plant preparations to treat the disease. Aim. In this study, we investigated the effect of hydroethanolic extract of Cordia vignei leaves (CVE) on acetic acid-induced UC in rats. Method. Male Sprague Dawley rats received oral treatment of either saline (10 ml/kg), sulfasalazine (500 mg/kg), or CVE (30-300 mg/kg) daily for 7 days. On day 4, colitis was induced by a single intrarectal administration of 500 μl of acetic acid (4% v/v). Rats were sacrificed on day 8 and colons were collected for histopathological examination. Blood was also collected for haematological assessment. Results. CVE significantly (P
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