An 80-year-old woman with myelofibrosis and diffuse mosaic attenuation on chest computed tomography

Autor: Harpreet Singh, Jonathan S. Kurman, Chinmay T. Jani, Nagarjun Rao, Bryan S. Benn
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Respiratory Medicine Case Reports, Vol 38, Iss , Pp 101705- (2022)
Druh dokumentu: article
ISSN: 2213-0071
DOI: 10.1016/j.rmcr.2022.101705
Popis: An 80-year-old woman with myelofibrosis sought evaluation for progressive dyspnea. Her past medical history included essential thrombocytosis, which transformed to myelofibrosis. Inspiratory computed tomography of chest showed diffuse mosaic attenuation with lymphadenopathy. Flexible bronchoscopy with lymph node and pulmonary parenchymal cryo biopsy revealed nodular deposits of extramedullary hematopoiesis in lung parenchyma and moderate to severe vascular medial and intimal thickening of pulmonary vasculature consistent with pulmonary parenchymal extramedullary hematopoiesis associated with pulmonary hypertension (a rare compensatory mechanism in myeloproliferative disorders). In this report, we explore the manifestations, pathogenesis, treatment, and prognosis of pulmonary extramedullary hematopoiesis reported in the literature.
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