Withania Somnifera: Correlation of Phytoconstituents with Hypolipidemic and Cardioprotective Activities
| Autor: | Subasini Uthirapathy, Tara F. Tahir |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | ARO-The Scientific Journal of Koya University, Vol 9, Iss 2 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2410-9355 2307-549X |
| DOI: | 10.14500/aro.10844 |
| Popis: | Withania somnifera (WS) (Dunal) or Ashwagandha is a well-known hypolipidemic herb and antioxidant. In this study, 75% ethanolic extract of WS is attempted to evaluate the cardioprotective activity of isoproterenol-induced cardiotoxicity and hypolipidemic activity in Triton WR 1339-induced hyperlipidemia. In addition, phytochemical evaluation of the same extracts analyzed by gas chromatography–mass spectrometer (GC–MS). This study found that 7 days of therapy with WS extracts at 1000 mg/kg b.wt. reduced cholesterol by 76%, low-density lipoprotein (LDL) by 71%, and TAG by 12% (P < 0.05). Furthermore, it can significantly reduce cholesterol and LDL levels (P < 0.05). Similarly, the use of 50 mg/kg b.wt. of WS extract showed a cardioprotective effect against isoproterenol-induced cardiac toxic rats. The antioxidants glutathione, glutathione peroxidase, and catalase are increased in WS extract (P < 0.05), whereas the release of cardiac indicators in heart tissue is reduced (P < 0.05). Furthermore, a 30-day treatment with WS also reduced triacylglycerol in isoprenaline-induced cardiotoxic rats. GC–MS analysis of the methanol fraction of the Ashwagandha 70% ethanolic extract showed the presence of higher concentrations of fatty acids. In conclusion, WS showed hypolipidemic and cardioprotective activities in diseased animals induced by isoproterenol and Triton WR 1339. |
| Databáze: | Directory of Open Access Journals |
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