| Autor: |
J. Russell Ravenel, Amy E. Perkins, Angela Tomczik, Ana Defendini, Helen K. Strnad, Elena Varlinskaya, Terrence Deak, Robert L. Spencer |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Aging Brain, Vol 5, Iss , Pp 100107- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2589-9589 |
| DOI: |
10.1016/j.nbas.2024.100107 |
| Popis: |
Social behavior decreases with aging, and we have previously found a substantial decline in social investigative behavior of old female rats. In this study we examined the neural activation pattern (c-Fos mRNA) of young (3 month) and old (18 month) female rats after brief 10 min exposure to a novel female rat in order to identify forebrain regions that show selective age-related alterations in their neural response to social investigation. We also measured relative oxytocin receptor expression (Oxtr mRNA) as a possible factor in age-related declines in c-Fos induction after social interaction. Young rats exposed to a social partner had a greater c-Fos mRNA response than those exposed to novel context alone in the lateral septum and septohypothalamic area, with blunted increases evident in old rats. In addition, c-Fos mRNA levels in the lateral septum were positively correlated with social investigative behavior. Interestingly, age-related differences in c-Fos gene induction were unrelated to the local amount of Oxtr expression within specific brain regions, although we found an age-related decline in Oxtr expression in the ventromedial hypothalamus. This functional neuroanatomical characterization may point to certain brain regions that are especially sensitive to age-related declines associated with social interaction behavior. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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