BCG vaccine modulates immune system of rats with
| Autor: | O. V. Zaitseva, D. O. Labudzynskyi, I. O. Shymanskyy, S. G. Shandrenko, M. M. Veliky |
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| Jazyk: | English<br />Ukrainian |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Біологічні студії, Vol 10, Iss 1, Pp 29-36 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1996-4536 2311-0783 87051109 |
| DOI: | 10.30970/sbi.1001.461 |
| Popis: | The study was carried out to investigate the effect of BCG vaccination on the functional activity of immune blood cells in rats with alimentary osteoporosis. The findings indicate that chronic vitamin D deficiency led to osteoporosis and caused immunological disturbances. In particular, phagocytic activity of granulocytes and monocytes and their ability to produce reactive oxygen species were found to be significantly decreased. It was also demonstrated a marked (2-fold) lowering of NAD(P)H-quinone oxidoreductase activity in leukocytes. Additional BCG vaccination of rats with developed alimentary osteoporosis resulted in excessive stimulation of non-specific immune response. Phagocytic activity of monocytes and granulocytes increased to values exceeding those in control rats. BCG induced elevation of NAD(P)H-quinone oxidoreductase activity in phagocytes that was accompanied by intensification of reactive oxygen species formation. These data suggest that administration of BCG increases the activity of phagocytic cells in the blood of osteoporotic rats, thus, leading to activation of non-specific immune defense. |
| Databáze: | Directory of Open Access Journals |
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