Eosinophilic esophagitis: Current concepts in diagnosis and management

Autor:	Fahad I. Alsohaibani, Musthafa C. Peedikayil, Mohammed A. Alzahrani, Nahla A. Azzam, Majid A. Almadi, Evan S. Dellon, Abdulrahman A. Al-Hussaini
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	eosinophilic esophagitis dupilumab dysphagia food impaction proton-pump inhibitor swallowed steroids Diseases of the digestive system. Gastroenterology RC799-869
Zdroj:	The Saudi Journal of Gastroenterology, Vol 30, Iss 4, Pp 210-227 (2024)
Druh dokumentu:	article
ISSN:	1319-3767 1998-4049
DOI:	10.4103/sjg.sjg_50_24
Popis:	Eosinophilic esophagitis is an antigen-mediated chronic inflammatory disorder that has risen in incidence and prevalence over the past 2 decades. The clinical presentation is variable and consists of mainly esophageal symptoms such as dysphagia, heartburn, food impaction, and vomiting. Current management relies on dietary elimination, proton-pump inhibitors, and topical corticosteroids with different response rates and relapses after treatment discontinuation. With a better understanding of the underlying pathophysiology, many molecules emerged recently as targeted treatment including dupilumab (IL4/IL13 blocker), as the first FDA-approved biological treatment, which has changed the management paradigm.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c315a80f8c02484cbf4263c037a5497b Zobrazit plný text záznamu View record in DOAJ