Eosinophilic esophagitis: Current concepts in diagnosis and management
Autor: | Fahad I. Alsohaibani, Musthafa C. Peedikayil, Mohammed A. Alzahrani, Nahla A. Azzam, Majid A. Almadi, Evan S. Dellon, Abdulrahman A. Al-Hussaini |
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Jazyk: | angličtina |
Rok vydání: | 2024 |
Předmět: | |
Zdroj: | The Saudi Journal of Gastroenterology, Vol 30, Iss 4, Pp 210-227 (2024) |
Druh dokumentu: | article |
ISSN: | 1319-3767 1998-4049 |
DOI: | 10.4103/sjg.sjg_50_24 |
Popis: | Eosinophilic esophagitis is an antigen-mediated chronic inflammatory disorder that has risen in incidence and prevalence over the past 2 decades. The clinical presentation is variable and consists of mainly esophageal symptoms such as dysphagia, heartburn, food impaction, and vomiting. Current management relies on dietary elimination, proton-pump inhibitors, and topical corticosteroids with different response rates and relapses after treatment discontinuation. With a better understanding of the underlying pathophysiology, many molecules emerged recently as targeted treatment including dupilumab (IL4/IL13 blocker), as the first FDA-approved biological treatment, which has changed the management paradigm. |
Databáze: | Directory of Open Access Journals |
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