Ganoaustralins A and B, Unusual Aromatic Triterpenes from the Mushroom Ganoderma australe

Autor:	Lin Zhou, He-Ping Chen, Xinyang Li, Ji-Kai Liu
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Ganoderma australe (Fr.) Pat. Polyporaceae triterpenes anti-BACE1 activity Medicine Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceuticals, Vol 15, Iss 12, p 1520 (2022)
Druh dokumentu:	article
ISSN:	1424-8247
DOI:	10.3390/ph15121520
Popis:	Two triterpenes, ganoaustralins A (1) and B (2), featuring unprecedented 6/6/6/5/6 scaffolds were isolated from the fruiting bodies of the mushroom Ganoderma australe. The structures were determined by extensive NMR and HRESIMS spectroscopic analysis. The absolute configuration of the C-25 in ganoaustralin A was assigned by the phenylglycine methyl ester (PGME) method. The relative and absolute configurations of the polycyclic backbones were determined by NMR and ECD calculations, respectively. The plausible biosynthetic pathways of ganoaustralins A and B were proposed. Ganoaustralin B showed weak inhibition against β-secretase 1.
Databáze:	Directory of Open Access Journals
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