Spirometric assessment of emphysema presence and severity as measured by quantitative CT and CT-based radiomics in COPD

Autor:	Mariaelena Occhipinti, Matteo Paoletti, Brian J. Bartholmai, Srinivasan Rajagopalan, Ronald A. Karwoski, Cosimo Nardi, Riccardo Inchingolo, Anna R. Larici, Gianna Camiciottoli, Federico Lavorini, Stefano Colagrande, Vito Brusasco, Massimo Pistolesi
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Pulmonary emphysema COPD Small airway disease Respiratory function tests Spirometry Tomography Diseases of the respiratory system RC705-779
Zdroj:	Respiratory Research, Vol 20, Iss 1, Pp 1-11 (2019)
Druh dokumentu:	article
ISSN:	1465-993X
DOI:	10.1186/s12931-019-1049-3
Popis:	Abstract Background The mechanisms underlying airflow obstruction in COPD cannot be distinguished by standard spirometry. We ascertain whether mathematical modeling of airway biomechanical properties, as assessed from spirometry, could provide estimates of emphysema presence and severity, as quantified by computed tomography (CT) metrics and CT-based radiomics. Methods We quantified presence and severity of emphysema by standard CT metrics (VIDA) and co-registration analysis (ImbioLDA) of inspiratory-expiratory CT in 194 COPD patients who underwent pulmonary function testing. According to percentages of low attenuation area below − 950 Hounsfield Units (%LAA-950insp) patients were classified as having no emphysema (NE) with %LAA-950insp
Databáze:	Directory of Open Access Journals
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