Mortality in a Cohort of HIV-Infected Children: A 12-Month Outcome of Antiretroviral Therapy in Makurdi, Nigeria

Autor: Emmanuel Ademola Anigilaje, Sunday Adedeji Aderibigbe
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Advances in Medicine, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 2356-6752
2314-758X
DOI: 10.1155/2018/6409134
Popis: Introduction. Recognizing the predictors of mortality among HIV-infected children will allow for concerted management that can reduce HIV-mortality in Nigeria. Methodology. A retrospective cohort study in children aged 0–15 years, between October 2010 and December 2013, at the Federal Medical Centre, Makurdi, Nigeria. Kaplan–Meier method analysed the cumulative probability of early mortality (EM) occurring at or before 6 months and after 6 months of follow-up (late mortality-LM) on a 12-month antiretroviral therapy (ART). Multivariate Cox proportional regression models were used to test for hazard ratios (HR). Results. 368 children were included in the analysis contributing 81 children per 100 child-years to the 12-month ART follow-up. A significant reduction in EM rates was noted at 17.3 deaths per 100 child-years (30 deaths) to LM rates of 3.0 deaths per 100 child-years (10 deaths), p
Databáze: Directory of Open Access Journals
Externí odkaz: