Neuroprotective effects of strength training in a neuroinflammatory animal model

Autor: Elizama de Gregório, Gabriela Cristiane Mendes, Lincon Bordignon Somensi, Cassio Geremia Freire, Luiza Freitas Lopes, Karine Ramires Lima, Guilherme Salgado Carrazoni, Ben-Hur Souto Neves, Steffanie Severo Picua, Luisa Mota da Silva, Pamela Billig Mello-Carpes, Juliana Sartori Bonini, Weber Claudio da Silva
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BMC Neuroscience, Vol 23, Iss 1, Pp 1-14 (2022)
Druh dokumentu: article
ISSN: 1471-2202
94470197
DOI: 10.1186/s12868-022-00708-w
Popis: Abstract Background The preventive role of muscular strength on diminishing neuroinflammation is yet unknown. In this study, the role of the prophylactic muscular strength exercise was investigated in order to verify whether it would diminish cognitive alterations and modify the antioxidant intracellular scenery in an animal neuroinflammatory model in of the CA1 region of the hippocampus. Methods The animals received muscular strength training (SE) three times a week for eight weeks. Subsequently, the stereotaxic surgery was performed with an intra-hippocampal infusion of either saline solution (SAL) or lipopolysaccharide (LPS). Next, we performed the behavioral tests: object recognition and social recognition. Then, the animals were euthanized, and their hippocampus and prefrontal cortex were collected. In another moment, we performed the dosage of the antioxidant activity and histological analysis. Results The results showed that the muscular strength exercises could show a beneficial prophylactic effect in the cognitive deficiencies caused by acute neuroinflammation. Regarding oxidative stress, there was an increase in catalase enzyme activity (CAT) in the group (SE + LPS) compared to the control groups (p
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje