| Autor: |
Raíssa Pinheiro de Mendonça, Giordanna Pereira Chemelo, Geovanni Pereira Mitre, Dimitra Castelo Branco, Natacha Malu Miranda da Costa, Fabrício Mesquita Tuji, Maria Sueli da Silva Kataoka, Ricardo Alves Mesquita, Sérgio de Melo Alves Júnior, João de Jesus Viana Pinheiro |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Diagnostic Pathology, Vol 15, Iss 1, Pp 1-8 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1746-1596 |
| DOI: |
10.1186/s13000-020-00967-3 |
| Popis: |
Abstract Background Among cancers affecting the oral cavity, adenoid cystic carcinoma (ACC) is a relatively common malignant neoplasm. It has high rates of metastasis and recurrence and is associated with significant morbidity. During the progression of ACC, the oxygen concentration is reduced in specific areas of the tumour microenvironment, leading to intratumoural hypoxia. The expression of NOTCH1, a disintegrin and metalloproteinase 12 (ADAM-12), hypoxia-inducible factor 1 alpha (HIF-1α), and heparin-binding epidermal growth factor (HB-EGF) under hypoxic conditions has been implicated in invadopodia formation, tumour invasiveness, and metastasis. The aim of this study was to analyse the expression of these proteins to elucidate the mechanisms underlying ACC invasiveness. Methods Fifteen ACC samples and 10 normal-looking salivary gland (SG) samples were used to investigate the expression of these proteins by immunohistochemistry. Primary antibodies against NOTCH1, ADAM-12, HIF-1α, and HB-EGF were used. Results The immunoexpression of all proteins was higher in ACC samples than in SG samples (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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