The Interaction Between N6-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers

Autor:	Lin Yao, Chang-Feng Man, Rong He, Lian He, Jia-Bin Huang, Shou-Yan Xiang, Zhe Dai, Xiao-Yan Wang, Yu Fan
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	m6A modification non-coding RNAs (ncRNAs) gastrointestinal tract cancers colorectal cancer long non-coding RNA (lncRNA) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Frontiers in Oncology, Vol 11 (2022)
Druh dokumentu:	article
ISSN:	2234-943X 55276318
DOI:	10.3389/fonc.2021.784127
Popis:	N6-methyladenosine (m6A) is the most common epigenetic modification of eukaryotic RNA, which can participate in the growth and development of the body and a variety of physiological and disease processes by affecting the splicing, processing, localization, transport, translation, and degradation of RNA. Increasing evidence shows that non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, can also regulate the RNA m6A modification process by affecting the expression of m6A-related enzymes. The interaction between m6A modification and non-coding RNAs provides a new perspective for the exploration of the potential mechanism of tumor genesis and development. In this review, we summarize the potential mechanisms and effects of m6A and non-coding RNAs in gastrointestinal tract cancers.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/311d0727f59941b88d80b55276318fe6 Zobrazit plný text záznamu View record in DOAJ