| Autor: |
Christina Doverhag, Maj Hedtjärn, Françoise Poirier, Carina Mallard, Henrik Hagberg, Anna Karlsson, Karin Sävman |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Neurobiology of Disease, Vol 38, Iss 1, Pp 36-46 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
1095-953X |
| DOI: |
10.1016/j.nbd.2009.12.024 |
| Popis: |
Inflammation induced by hypoxia–ischemia (HI) contributes to the development of injury in the newborn brain. In this study, we investigated the role of galectin-3, a novel inflammatory mediator, in the inflammatory response and development of brain injury in a mouse model for neonatal HI. Galectin-3 gene and protein expression was increased after injury and galectin-3 was located in activated microglia/macrophages. Galectin-3-deficient mice (gal3−/−) were protected from injury particularly in hippocampus and striatum. Microglia accumulation was increased in the gal3−/− mice but accompanied by decreased levels of total matrix metalloproteinase (MMP)-9 and nitrotyrosine. The protection and increase in microglial infiltration was more pronounced in male gal3−/− mice. Trophic factors and apoptotic markers did not significantly differ between groups. In conclusion, galectin-3 contributes to neonatal HI injury particularly in male mice. Our results indicate that galectin-3 exerts its effect by modulating the inflammatory response. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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