Circulating neutrophil extracellular trap remnants as a biomarker to predict outcomes in lupus nephritis
| Autor: | Dafna D Gladman, Murray Urowitz, Zahi Touma, Joan Wither, Laura Patricia Whittall-Garcia, Farnoosh Naderinabi, Ana Konvalinka |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Lupus Science and Medicine, Vol 11, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2053-8790 31488285 |
| DOI: | 10.1136/lupus-2023-001038 |
| Popis: | Objective To determine if the serum levels of neutrophil extracellular trap (NET) remnants (Elastase-DNA and HMGB1-DNA complexes) at the time of a lupus nephritis (LN) flare predict renal outcomes in the following 24 months.Methods This was a retrospective study performed in prospectively followed cohorts. The study included two cohorts: an exploratory cohort to assess the association between NET remnant levels and the presence of active LN, and a separate LN cohort to determine the utility of NET remnants to predict renal outcomes over the subsequent 24 months.Results Ninety-two individuals were included in the exploratory cohort (49 active systemic lupus erythematosus (SLE), 23 inactive SLE and 20 healthy controls (HC)). NET remnants were significantly higher in patients with SLE patients compared with HC (p |
| Databáze: | Directory of Open Access Journals |
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