Immediate Outcomes of Surgical Treatment for Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis

Autor: D. B. Giller, S. S. Saenko, A. N. Gerasimov, G. V. Shcherbakova, A. A. Popova, V. A. Basangova, A. N. Ilyukhin, O. Sh. Kesaev, E. A. Bagdasaryan
Jazyk: ruština
Rok vydání: 2024
Předmět:
Zdroj: Инновационная медицина Кубани, Vol 0, Iss 3, Pp 8-15 (2024)
Druh dokumentu: article
ISSN: 2541-9897
DOI: 10.35401/2541-9897-2024-9-3-8-15
Popis: Objective: To study and compare surgical risks and immediate effectiveness of surgical treatment in patients with multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB).Materials and methods: We examined immediate treatment outcomes of 1180 patients who underwent surgery for destructive MDRTB, pre-XDR-TB, and XDR-TB between 2011 and 2023. The patients were grouped: group 1 for patients with MDR-TB (744 cases) and group 2 for patients with pre-XDR-TB and XDR-TB (436 cases). Moreover, patients were further subdivided based on the extent of surgery.Results: The complete clinical response, ie, cavity closure and elimination of bacilli (CV-, MBT-), was achieved in all 405 patients who underwent radical surgery, in 673 (97.1%) of 694 patients who underwent semiradical surgery, and only in 10 (12.3%) of 81 patients who underwent palliative surgery.Conclusions: The immediate outcomes of surgical treatment for MDR-TB were superior in all parameters compared with those for pre-XDR-TB and XDR-TB; however, we found no significant differences when we evaluated treatment effectiveness in patients who underwent radical and semiradical surgery.
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