Clinical Factors Influencing Phenotype of HCMV-Specific CD8+ T Cells and HCMV-Induced Interferon-Gamma Production after Allogeneic Stem Cells Transplantation
| Autor: | Inmaculada Gayoso, Sara Cantisán, Carolina Cerrato, Joaquín Sánchez-García, Carmen Martin, Rafael Solana, Antonio Torres-Gomez, Julian Torre-Cisneros |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Clinical and Developmental Immunology, Vol 2013 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1740-2522 1740-2530 |
| DOI: | 10.1155/2013/347213 |
| Popis: | Human cytomegalovirus (HCMV) infection causes significant morbidity and mortality after hematopoietic stem cell transplantation (HSCT). In this work, we characterized the phenotype and interferon-gamma (INF-γ) production of HCMV-specific T cells using QuantiFERON-HCMV assay in 26 patients 6 months after HSCT. We analysed whether these two parameters were associated with clinical variables. Our results showed that the patients receiving stem cells from donors ≥40 years old were 12 times more likely to have HCMV-specific CD8+ T cells with “differentiated phenotype” (CD45RA+CCR7+ ≤6.7% and CD28+ ≤30%) than patients grafted from donors |
| Databáze: | Directory of Open Access Journals |
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