Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration

Autor:	Andrew Campbell, Jessica M. Hogestyn, Christopher J. Folts, Brittany Lopez, Christoph Pröschel, David Mock, Margot Mayer-Pröschel
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	Medicine Science
Zdroj:	Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-017-04432-y
Popis:	Abstract Progression of demyelinating diseases is caused by an imbalance of two opposing processes: persistent destruction of myelin and myelin repair by differentiating oligodendrocyte progenitor cells (OPCs). Repair that cannot keep pace with destruction results in progressive loss of myelin. Viral infections have long been suspected to be involved in these processes but their specific role remains elusive. Here we describe a novel mechanism by which HHV-6A, a member of the human herpesvirus family, may contribute to inadequate myelin repair after injury.
Databáze:	Directory of Open Access Journals
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