Autor: |
Zhen Yang, Wenjie Xiong, Ruoyun Yang, Haisheng Qian, Zhi He, Meihong Chen, Jiajia Yang, Huaiming Sang, Jin Yan, Xiaobing Xu, Yun Wang, Guoxin Zhang, Feng Ye |
Jazyk: |
angličtina |
Rok vydání: |
2023 |
Předmět: |
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Zdroj: |
Gut Pathogens, Vol 15, Iss 1, Pp 1-9 (2023) |
Druh dokumentu: |
article |
ISSN: |
1757-4749 |
DOI: |
10.1186/s13099-023-00556-x |
Popis: |
Abstract Background The day-to-day (DTD) management model encourages patients to actively participate in their healthcare by setting goals. We determined the effectiveness of the DTD model in the treatment of Helicobacter pylori (H. pylori) infection, as compared with conventional outpatient education (OE). Methods We randomized 254 H. pylori-positive patients into a DTD group (127 patients) and an OE group (127 patients) prior to primary treatment with 14-day bismuth-containing quadruple therapy, including esomeprazole, amoxicillin, and clarithromycin. Both groups received consistent medication instructions. Patients in the DTD group recorded daily attendance after completing their daily medication plan from day 1 to day 14. The medication compliance, follow-up compliance, H. pylori eradication rates, and adverse events (AEs) were evaluated. Results In the modified intention-to-treat (MITT) and per-protocol (PP) analyses, the DTD group showed significantly higher medication compliance than the OE group (P = 0.001 and P = 0.031, respectively). Both the MITT and PP analyses showed significant differences in follow-up compliance (P |
Databáze: |
Directory of Open Access Journals |
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