Denosumab as the Treatment of Recalcitrant Tuberculous Pleural Effusion-Associated Hypercalcemia
| Autor: | Afdhal Afiq Abd Jalil, Sharifah Faradila Wan Muhamad Hatta, Aimi Fadilah Mohamad, Mohammed Fauzi Abdul Rani |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Case Reports in Medicine, Vol 2021 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1687-9627 1687-9635 |
| DOI: | 10.1155/2021/5544848 |
| Popis: | Denosumab is a human monoclonal antibody that binds to RANKL (receptor activator of nuclear factor-kappa B ligand). It has mainly been used in the treatment of osteoporosis for a variety of causes especially in situations refractory to bisphosphonates or when kidney function is impaired. It is also used in cases of malignancy-associated hypercalcemia. There are many causes of hypercalcemia, but only rarely it is associated with granulomatous diseases such as tuberculous pleural effusion. We report a case of hypercalcemia from tuberculous pleural effusion that was initially admitted with left medium abundance pleural effusion and a serum corrected calcium level of 3.48 mmol/L. The calcium level was successfully normalized within 72 hours of subcutaneous denosumab administration after other interventions have failed. |
| Databáze: | Directory of Open Access Journals |
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