Cytotoxic flavonoids from Erythrina caffra Thunb
| Autor: | Z. Y. Desta, N. Sewald, R. R.T. Majinda |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Bulletin of the Chemical Society of Ethiopia, Vol 30, Iss 3, Pp 427-435 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1011-3924 1726-801X |
| DOI: | 10.4314/bcse.v30i3.11 |
| Popis: | Erythrina caffra is an important medicinal plant native to South Africa. Its stem bark was investigated for the flavonoid constituents and biological activity. Some isolated flavonoids, 3, 5, 6, 8, 9, 10, 11, 12, 13, 15 and 16 were found to be active against the human cervix carcinoma KB-3-1 cells with IC50 values in the micromolar range. Compounds 8, 9, 11, 13 and 15 also showed weak to moderate antibacterial activity against some organisms using the disc diffusion assay at loadings of 62.5 μg/disc (8, 11) and 125 μg/disc (9, 13, 15). |
| Databáze: | Directory of Open Access Journals |
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