Diversity and composition of gut microbiota in healthy individuals and patients at different stages of hepatitis B virus-related liver disease

Autor:	Meng-Ju Lin, Tung-Hung Su, Chieh-Chang Chen, Wei-Kai Wu, Shih-Jer Hsu, Tai-Chung Tseng, Sih-Han Liao, Chun-Ming Hong, Hung-Chih Yang, Chun-Jen Liu, Ming-Shiang Wu, Jia-Horng Kao
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Hepatitis B virus Resolved hepatitis B virus infection Liver cirrhosis Hepatocellular carcinoma Gut microbiota 16S rRNA sequencing Diseases of the digestive system. Gastroenterology RC799-869
Zdroj:	Gut Pathogens, Vol 15, Iss 1, Pp 1-12 (2023)
Druh dokumentu:	article
ISSN:	1757-4749
DOI:	10.1186/s13099-023-00549-w
Popis:	Abstract Background Hepatitis B virus (HBV) causes chronic hepatitis B (CHB), liver cirrhosis, and hepatocellular carcinoma. The evolution of human gut microbiota during the progression of HBV-related liver diseases remains unclear. Therefore, we prospectively enrolled patients with HBV-related liver diseases and healthy individuals. Through 16S ribosomal RNA amplicon sequencing, we characterized the gut microbiota of the participants and predicted the functions of microbial communities. Results We analyzed the gut microbiota of 56 healthy controls and 106 patients with HBV-related liver disease [14 with resolved HBV infection, 58 with CHB, and 34 with advanced liver disease (15 with liver cirrhosis and 19 with hepatocellular carcinoma)]. Patients with HBV-related liver disease exhibited a higher degree of bacterial richness (all P
Databáze:	Directory of Open Access Journals
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